ZNF121 and NCAN

Data Source:
BioGRID (proximity labelling technology)

		ZNF121	NCAN
Description		zinc finger protein 121	neurocan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process
Pathways			A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs			Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS			Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		8 interacting genes: BARD1 CARD9 KEAP1 KRTAP10-8 RBAK TRIM41 ZNF835 ZNF837	8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR
Entrez ID		7675	1463
HPRD ID		15952	02897
Ensembl ID		ENSG00000197961	ENSG00000130287
Uniprot IDs		P58317	A0A024R7M3 O14594 Q4LE67
PDB IDs
Enriched GO Terms of Interacting Partners?
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