ZIC3 and DNAI1

Data Source:
BioGRID (two hybrid)

		ZIC3	DNAI1
Description		Zic family member 3	dynein axonemal intermediate chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoskeleton Microtubule Cilium Outer Dynein Arm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Heart Looping Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Central Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation Lung Development Somatic Stem Cell Population Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry	Cilium Movement Microtubule-based Movement Determination Of Left/right Symmetry Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases		Heterotaxy; Situs ambiguus	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Refractive error ( 32231278)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		5 interacting genes: CTNNB1 GLI3 SRF TP53 TWIST1	2 interacting genes: PAFAH1B1 SQSTM1
Entrez ID		7547	27019
HPRD ID		02225	05080
Ensembl ID		ENSG00000156925	ENSG00000122735
Uniprot IDs		O60481	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs		2EJ4 2RPC
Enriched GO Terms of Interacting Partners?
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