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ZIC1 and GLI2
Data Source:
HPRD
(in vivo, in vitro)
ZIC1
GLI2
Description
Zic family member 1
GLI family zinc finger 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Cilium
Axoneme
Membrane
Nuclear Speck
Motile Cilium
Ciliary Tip
Ciliary Base
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Pattern Specification Process
Central Nervous System Development
Brain Development
Regulation Of Smoothened Signaling Pathway
Cell Differentiation
Positive Regulation Of Protein Import Into Nucleus
Inner Ear Morphogenesis
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
In Utero Embryonic Development
Kidney Development
Chondrocyte Differentiation
Osteoblast Development
Regulation Of Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Pattern Specification Process
Axon Guidance
Ventral Midline Development
Hindgut Morphogenesis
Heart Development
Anterior/posterior Pattern Specification
Proximal/distal Pattern Formation
Floor Plate Formation
Spinal Cord Dorsal/ventral Patterning
Ventral Spinal Cord Development
Cerebellar Cortex Morphogenesis
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Spinal Cord Ventral Commissure Morphogenesis
Pituitary Gland Development
Lung Development
Mammary Gland Development
Hindbrain Development
Hair Follicle Morphogenesis
Negative Regulation Of Chondrocyte Differentiation
Positive Regulation Of T Cell Differentiation In Thymus
Tube Development
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Digestive Tract Development
Developmental Growth
Neuron Development
Branching Morphogenesis Of An Epithelial Tube
Notochord Regression
Prostatic Bud Formation
Mammary Gland Duct Morphogenesis
Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Cellular Response To Organic Cyclic Compound
Cochlea Morphogenesis
Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways
Degradation of GLI2 by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
GLI proteins bind promoters of Hh responsive genes to promote transcription
RUNX2 regulates chondrocyte maturation
Drugs
Diseases
Holoprosencephaly (HPE)
GWAS
Adult body size (
32376654
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chin dimples (
27182965
)
Cortical surface area (MOSTest) (
32665545
)
Daytime sleep phenotypes (
27126917
)
Monobrow (
27182965
)
Multiple sclerosis (
19010793
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Acne (severe) (
30542056
)
Age-related macular degeneration (
23326517
)
Breast size (
22747683
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Estimated glomerular filtration rate (
31015462
)
Estimated glomerular filtration rate in coronary artery disease and impaired kidney function (
30809046
)
Glomerular filtration rate (creatinine) (
26831199
)
Height (
28552196
25429064
31562340
)
Serum uric acid levels (
30993211
)
Type 2 diabetes (
30054458
30297969
)
Interacting Genes
71 interacting genes:
ABHD11
ANKRD10
ARID5A
ATP23
BBS4
C11orf1
CDPF1
CRX
CYSRT1
DAPL1
EEF1AKMT3
FAM168B
FOXH1
GLI1
GLI2
GLI3
INTS11
KLHL26
KRT31
KRT34
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP19-1
KRTAP19-2
KRTAP19-5
KRTAP19-7
KRTAP21-2
KRTAP22-1
KRTAP3-2
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LITAF
MAGED1
METTL27
MGAT5B
NFKBID
OIP5
OXER1
PATZ1
PEF1
PLAAT1
PLSCR3
RBPMS
REL
RFC2
RNF144B
RUSC1
SMAD4
SMUG1
SPAG8
SPATS1
SUFU
TBX19
TEPSIN
TLE5
TRAF1
TRIP6
TSC1
UBE2I
UFSP1
WWOX
YPEL3
ZNF34
ZNF474
ZNF620
12 interacting genes:
AR
BTRC
CREB1
FBXW11
OTUB2
SKI
SPOP
STK36
SUFU
TAF9
ZIC1
ZIC2
Entrez ID
7545
2736
HPRD ID
02718
01312
Ensembl ID
ENSG00000152977
ENSG00000074047
Uniprot IDs
Q15915
P10070
Q1PSW9
Q59FV5
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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