ZFP36 and EDC3

Data Source:
HPRD (in vitro, in vivo)

		ZFP36	EDC3
Description		ZFP36 ring finger protein	enhancer of mRNA decapping 3
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GO Annotations	Cellular Component	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex RISC-loading Complex Ribonucleoprotein Complex	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Viral Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA Mediated Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Gene Silencing By MiRNA	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS			Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Mean platelet volume ( 32888494)
Interacting Genes		26 interacting genes: APP ATG16L1 CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17	11 interacting genes: ANXA10 DCP1B DDX6 EFHC2 LNX1 MIR15B PIAS2 QARS1 YWHAB YWHAG ZFP36
Entrez ID		7538	80153
HPRD ID		01835	07954
Ensembl ID		ENSG00000128016	ENSG00000179151
Uniprot IDs		M0QY76 P26651	Q96F86
PDB IDs		4J8S	2VC8 2WAX 2WAY 3D3J 3D3K 6S8S
Enriched GO Terms of Interacting Partners?
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