GET1 and RASGRP3

Data Source:
BioGRID (two hybrid)

		GET1	RASGRP3
Description		guided entry of tail-anchored proteins factor 1	RAS guanyl releasing protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Kinase Binding Diacylglycerol Binding Small GTPase Binding
	Biological Process	Tail-anchored Membrane Protein Insertion Into ER Membrane	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 28714469 19838193)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		7485	25780
HPRD ID		04224	15213
Ensembl ID		ENSG00000182093	ENSG00000152689
Uniprot IDs		O00258	Q8IV61
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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