WNT6 and PORCN

Data Source:
HPRD (in vitro, in vivo)

		WNT6	PORCN
Description		Wnt family member 6	porcupine O-acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse
	Molecular Function	Frizzled Binding Cytokine Activity	Transferase Activity, Transferring Acyl Groups Wnt-protein Binding Palmitoleoyltransferase Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Neuron Differentiation Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Epithelial-mesenchymal Cell Signaling Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Retinoic Acid Nephron Tubule Formation	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoylation Lipid Modification Protein Palmitoleylation Canonical Wnt Signaling Pathway Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking LGK974 inhibits PORCN
Drugs
Diseases			Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS		Height ( 31562340) Male-pattern baldness ( 28196072) Reticulocyte count ( 32888494)
Interacting Genes		2 interacting genes: PORCN RHOU	9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID		7475	64840
HPRD ID		05233	06680
Ensembl ID		ENSG00000115596	ENSG00000102312
Uniprot IDs		Q8N2E5 Q9Y6F9	Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
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