WNT3 and FZD1

Data Source:
HPRD (in vivo)

		WNT3	FZD1
Description		Wnt family member 3	frizzled class receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Wnt Signalosome	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Wnt Signalosome
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Stem Cell Proliferation	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Neuron Projection Development Neuron Differentiation Autocrine Signaling Non-canonical Wnt Signaling Pathway Response To Drug Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Presynapse Assembly Beta-catenin Destruction Complex Disassembly Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases		Tetra-amelia
GWAS		Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Parkinson's disease ( 22451204 21812969) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278)	Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)
Interacting Genes		1 interacting genes: FZD1	6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		7473	8321
HPRD ID		01318	04558
Ensembl ID		ENSG00000108379	ENSG00000157240
Uniprot IDs		P56703	Q9UP38
PDB IDs		6AHY
Enriched GO Terms of Interacting Partners?
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