NSD2 and MDC1

Data Source:
BioGRID (proximity labelling technology, unspecified method)

		NSD2	MDC1
Description		nuclear receptor binding SET domain protein 2	mediator of DNA damage checkpoint 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases		Multiple myeloma
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		12 interacting genes: AGO2 APP AR AURKA ESR1 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2	40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		7468	9656
HPRD ID		04259	16252
Ensembl ID		ENSG00000109685	ENSG00000137337
Uniprot IDs		O96028	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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