VRK2 and CNTN5

Data Source:
BioGRID (two hybrid)

		VRK2	CNTN5
Description		VRK serine/threonine kinase 2	contactin 5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Extracellular Region Plasma Membrane GABA-ergic Synapse Anchored Component Of Presynaptic Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Viral Process Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Cell Adhesion Sensory Perception Of Sound Presynapse Assembly
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression ( 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alcohol dependence ( 26365420) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 29273806) Atrial fibrillation ( 17903304) Behcet's disease ( 27548383) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576 29875488 28240269) Bone mineral density (femoral neck) ( 26911590) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Diastolic blood pressure ( 27841878) Factor VII activity ( 30642921) Feeling miserable ( 29500382) Fructosamine levels ( 29844224) Glycated hemoglobin levels ( 28898252) Gout vs. Hyperuricemia ( 31289104) Immune reponse to smallpox (secreted IL-2) ( 22610502) Loneliness (multivariate analysis) ( 27629369) Myopia (pathological) ( 23049088) Neurological blood protein biomarker levels ( 31320639) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Plasma kynurenine levels in major depressive disorder ( 29317604) Spatial memory ( 31596458) Total glycated albumin levels ( 29844224) Volumetric brain MRI ( 17903297) Waist-hip ratio ( 25673412)
Interacting Genes		18 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88
Entrez ID		7444	53942
HPRD ID		03702	06241
Ensembl ID		ENSG00000028116	ENSG00000149972
Uniprot IDs		A8K9L2 Q86Y07	O94779
PDB IDs		2V62 5UU1 6NCG	4N68 5E52
Enriched GO Terms of Interacting Partners?
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