VEGFC and FLT4

Data Source:
HPRD (in vivo)

		VEGFC	FLT4
Description		vascular endothelial growth factor C	fms related receptor tyrosine kinase 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Vascular Endothelial Growth Factor Receptor 3 Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Platelet Degranulation Substrate-dependent Cell Migration Signal Transduction Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Protein Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Secretion Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Positive Regulation Of Lymphangiogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Hematopoietic Progenitor Cell Differentiation Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Sorafenib Sunitinib Vatalanib TG-100801 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Fostamatinib Selpercatinib
Diseases		Gastric cancer	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Blood protein levels ( 30072576 29875488) Chin dimples ( 27182965) HIV-1 viral setpoint ( 22174851) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Serum albumin level ( 29403010) Serum total protein level ( 29403010) Thyroid stimulating hormone levels ( 32769997)	Blood protein levels ( 30072576 29875488) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)
Interacting Genes		3 interacting genes: FLT4 KDR SGTB	16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD
Entrez ID		7424	2324
HPRD ID		03317	00636
Ensembl ID		ENSG00000150630	ENSG00000037280
Uniprot IDs		P49767	P35916
PDB IDs		2X1W 2X1X 4BSK	4BSJ 4BSK
Enriched GO Terms of Interacting Partners?
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