USP1 and KLHDC2

Data Source:
BioGRID (unspecified method)

		USP1	KLHDC2
Description		ubiquitin specific peptidase 1	kelch domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Nuclear Body Nuclear Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity	Protein Binding
	Biological Process	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		15 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K	5 interacting genes: EZH2 SELENOK SELENOS STRN4 USP1
Entrez ID		7398	23588
HPRD ID		04593	08824
Ensembl ID		ENSG00000162607	ENSG00000165516
Uniprot IDs		O94782	Q9Y2U9
PDB IDs		6DO5	6DO3 6DO4 6DO5
Enriched GO Terms of Interacting Partners?
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