USP4 and CIAO2B

Data Source:
BioGRID (two hybrid)

		USP4	CIAO2B
Description		ubiquitin specific peptidase 4	cytosolic iron-sulfur assembly component 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Midbody MMXD Complex CIA Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface	Chromosome Segregation Iron-sulfur Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer Protein Maturation By [4Fe-4S] Cluster Transfer
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	5 interacting genes: CIAO1 ERRFI1 MTNR1A PAXIP1 USP4
Entrez ID		7375	51647
HPRD ID		04598	13033
Ensembl ID		ENSG00000114316	ENSG00000166595
Uniprot IDs		A0A024R2X6 A1LPW7 Q08AK7 Q13107	Q9Y3D0
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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