UMPS and RB1CC1

Data Source:
BioGRID (two hybrid)

		UMPS	RB1CC1
Description		uridine monophosphate synthetase	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Pyrimidine Nucleobase Biosynthetic Process Cellular Response To Drug 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Macroautophagy Regulation Of Macroautophagy Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Pyrimidine biosynthesis	Macroautophagy
Drugs		6-hydroxyuridine-5'-phosphate
Diseases		Orotic aciduria
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		15 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 ZNF227	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		7372	9821
HPRD ID		02022	06019
Ensembl ID		ENSG00000114491	ENSG00000023287
Uniprot IDs		A8K5J1 P11172	Q8TDY2
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP	6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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