TYRO3 and PROS1

Data Source:
HPRD (in vivo)

		TYRO3	PROS1
Description		TYRO3 protein tyrosine kinase	protein S
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Fostamatinib	Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases			Inherited thrombophilia
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		28 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 GRB2 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1	10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3
Entrez ID		7301	5627
HPRD ID		02641	01473
Ensembl ID		ENSG00000092445	ENSG00000184500
Uniprot IDs		H0YNK6 Q06418	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		1RHF	1Z6C
Enriched GO Terms of Interacting Partners?
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