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PRR20B and ROR2
Data Source:
BioGRID
(two hybrid)
PRR20B
ROR2
Description
proline rich 20B
receptor tyrosine kinase like orphan receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Neuronal Cell Body
Receptor Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Activity
Frizzled Binding
Protein Binding
ATP Binding
Wnt-protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Metal Ion Binding
Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
Biological Process
Cartilage Condensation
Somitogenesis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Smoothened Signaling Pathway
JNK Cascade
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Neuron Projection Development
Astrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Embryonic Genitalia Morphogenesis
Male Genitalia Development
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Embryonic Digit Morphogenesis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Cell Fate Commitment
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Synaptic Transmission, Glutamatergic
Wnt Signaling Pathway, Planar Cell Polarity Pathway
SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Kinase C Activity
Macrophage Migration
Pathways
PCP/CE pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
Brachydactyly, including: type A; type B; type D; type E
Robinow syndrome
GWAS
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bipolar disorder and schizophrenia (
22688191
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Facial morphology (
31763980
)
Iris color (L* coordinate) (
30895295
)
Nose size (
27182965
)
Offspring birth weight (
31043758
)
Serum immune biomarker levels (
32066700
)
Type 2 diabetes (
25483131
)
Interacting Genes
89 interacting genes:
ABI2
ANKHD1
ARID5A
ATXN1
BANP
BEND2
BHLHE40
BICRAL
C10orf55
C1orf94
C3orf36
CABP2
CCNK
CDC37
CELF4
DAZAP2
DMRT3
DVL3
EIF4ENIF1
ESRP1
FAM168A
FAM222B
FAM9A
FOXH1
FOXP3
GLIS2
GTF2A1
HIVEP1
HLX
HYPK
KRTAP19-1
KRTAP19-5
LASP1
MAGED1
MBNL3
NCK2
NFYC
NOTCH3
NTAQ1
OXER1
PATZ1
PHF1
PITX1
POGZ
POU2F1
POU6F2
PRR20A
PRR20C
PRR20D
PRR20E
PRR34
PRR35
PTTG2
RBM23
RBM42
RBPMS
RBPMS2
RHOXF2
RIPPLY1
RNF4
ROR2
SAMD11
SH3RF1
SIAH1
SMAP1
SNRPB
SNRPC
SP4
SRPK2
TBX3
TBX6
TCF7L2
TFG
THAP1
TIAL1
TLX3
TOLLIP
TPRX1
TRIM35
VAC14
VENTX
VEZF1
VPS37C
YPEL3
ZBTB32
ZC3H10
ZCCHC14
ZNF385C
ZNF683
74 interacting genes:
ALG13
ARID5A
ATXN7L1
BHLHE40
C10orf55
C19orf54
C1orf94
C3orf56
CDC14A
CDC25C
CREM
CRX
DAB1
DAZAP2
DUSP1
DUSP10
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
DUSP6
ERBB2
EYA2
FAM168B
FOSB
FZD2
FZD5
HIVEP1
IKBKG
ILKAP
ISX
KRTAP19-7
KRTAP6-2
KRTAP7-1
LHX6
MAGED1
MAP3K7
MSX2
MTMR1
MTMR2
MTMR6
MTMR9
PITX1
PLA2G10
POU2AF1
PPM1A
PPM1B
PPM1F
PPP3CB
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRR
RBPMS
SOX14
STOX1
STYX
TAB1
TENT5A
TLX3
TPTE
VENTX
WNT5A
ZMYM4
ZNF34
Entrez ID
729233
4920
HPRD ID
19668
03822
Ensembl ID
ENSG00000204918
ENSG00000169071
Uniprot IDs
P86478
P86479
P86480
P86481
P86496
Q01974
PDB IDs
3ZZW
4GT4
6OSH
6OSN
6OSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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