TNFSF4 and SMG7

Data Source:
BioGRID (affinity chromatography technology)

		TNFSF4	SMG7
Description		TNF superfamily member 4	SMG7 nonsense mediated mRNA decay factor
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation
Pathways		TNFs bind their physiological receptors	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 31361310 30929738 27182965 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 27399966 26502338 28714469)
Interacting Genes		2 interacting genes: TNFRSF4 TRAF2	4 interacting genes: FGFR3 MDM2 SIRPA SMG5
Entrez ID		7292	9887
HPRD ID		04668	10723
Ensembl ID		ENSG00000117586	ENSG00000116698
Uniprot IDs		A0A024R937 P23510	E9PD50 Q6TV06 Q92540
PDB IDs		2HEV	1YA0
Enriched GO Terms of Interacting Partners?
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