CDK11A and B4GALT1

Data Source:
BioGRID (pull down)

		CDK11A	B4GALT1
Description		cyclin dependent kinase 11A	beta-1,4-galactosyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of MRNA Processing	Epithelial Cell Development Acute Inflammatory Response Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Population Proliferation Oligosaccharide Biosynthetic Process Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Neutrophil Degranulation Development Of Secondary Sexual Characteristics Leukocyte Migration Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Glycosylation
Pathways		Recruitment of mitotic centrosome proteins and complexes	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation
Drugs			N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Body mass index ( 26426971)	Aspartate aminotransferase levels ( 29403010) Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) Influenza A (H1N1) infection ( 26379185) Mild influenza (H1N1) infection ( 26379185) N-glycan levels ( 31163085) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Severe influenza A (H1N1) infection ( 26379185) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		6 interacting genes: B4GALT1 CCNL1 EIF3F GADD45A PIN1 SKIV2L	8 interacting genes: CDK11A EGFR LALBA OR10G4 TFRC TUBA1A TUBA4A TUBB
Entrez ID		728642	2683
HPRD ID			00659
Ensembl ID		ENSG00000008128	ENSG00000086062
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	P15291
PDB IDs			2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
Enriched GO Terms of Interacting Partners?
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