C5AR1 and RPS19

Data Source:
HPRD (in vivo)

		C5AR1	RPS19
Description		complement C5a receptor 1	ribosomal protein S19
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Secretory Granule Membrane Apical Part Of Cell	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome
	Molecular Function	Complement Component C5a Binding Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Proliferation In Hindbrain Regulation Of Complement Activation Neutrophil Chemotaxis Animal Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization Regulation Of Tau-protein Kinase Activity	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Monocyte Chemotaxis RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Nucleolus Organization Response To Extracellular Stimulus Viral Transcription Erythrocyte Differentiation Maturation Of SSU-rRNA Killing Of Cells Of Other Organism Ribosomal Small Subunit Biogenesis Defense Response To Gram-negative Bacterium Positive Regulation Of Cellular Component Movement Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Chronic periodontitis ( 25008200)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	6 interacting genes: APP C5AR1 FGF2 RPS19BP1 SPG21 TXNDC11
Entrez ID		728	6223
HPRD ID		00224	04591
Ensembl ID		ENSG00000197405	ENSG00000105372
Uniprot IDs		P21730	B0ZBD0 P39019
PDB IDs		5O9H 6C1Q 6C1R	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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