TTF1 and NFATC3

Data Source:
HPRD (in vivo)

		TTF1	NFATC3
Description		transcription termination factor 1	nuclear factor of activated T cells 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription, Termination Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication Cellular Protein Metabolic Process	Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Multicellular Organism Development Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Transcription Termination	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs
Diseases		Benign hereditary chorea
GWAS			Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: BAZ2A CAVIN1 KAT2B NFATC3 SMAD1 SMAD7	6 interacting genes: CDK6 CSNK1A1 FOS MAPK8 MAPK9 TTF1
Entrez ID		7270	4775
HPRD ID		02866	04077
Ensembl ID		ENSG00000125482	ENSG00000072736
Uniprot IDs		A0A024R8C1 A0A087WY09 Q15361	B5B2S0 B5B2S1 Q12968
PDB IDs			2XRW 2XS0
Enriched GO Terms of Interacting Partners?
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