TRPM2 and TRPC6

Data Source:
HPRD (in vitro, in vivo)

		TRPM2	TRPC6
Description		transient receptor potential cation channel subfamily M member 2	transient receptor potential cation channel subfamily C member 6
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Purine-containing Compound Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Neutrophil Degranulation Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Regulation Of Actin Cytoskeleton Reorganization	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		TRP channels Neutrophil degranulation	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: EFHC1 ITPR3 TRPC6	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		7226	7225
HPRD ID		04777	04710
Ensembl ID		ENSG00000142185	ENSG00000137672
Uniprot IDs		B4DVI8 O94759 Q14DR2	Q9Y210
PDB IDs		6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU	5YX9 6UZ8 6UZA 7A6U
Enriched GO Terms of Interacting Partners?
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