TRPM2 and TRAPPC10

Data Source:
BioGRID (proximity labelling technology)

		TRPM2	TRAPPC10
Description		transient receptor potential cation channel subfamily M member 2	trafficking protein particle complex subunit 10
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Golgi Membrane Cytosol TRAPP Complex TRAPPII Protein Complex
	Molecular Function	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity	Protein Binding
	Biological Process	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Purine-containing Compound Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Neutrophil Degranulation Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Regulation Of Actin Cytoskeleton Reorganization	Intra-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport COPII Vesicle Coating
Pathways		TRP channels Neutrophil degranulation	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		3 interacting genes: EFHC1 ITPR3 TRPC6	5 interacting genes: TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8
Entrez ID		7226	7109
HPRD ID		04777	03656
Ensembl ID		ENSG00000142185	ENSG00000160218
Uniprot IDs		B4DVI8 O94759 Q14DR2	P48553
PDB IDs		6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU
Enriched GO Terms of Interacting Partners?
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