C3AR1 and C4A

Data Source:
HPRD (in vitro)

		C3AR1	C4A
Description		complement C3a receptor 1	complement C4A (Rodgers blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Azurophil Granule Membrane Specific Granule Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Receptor Activity Complement Component C3a Receptor Activity G Protein-coupled Receptor Activity	Complement Component C1q Complex Binding Endopeptidase Inhibitor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Regulation Of Complement Activation Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs			Human immunoglobulin G
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: C3 C4A SNTA1	7 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 MASP2
Entrez ID		719	720
HPRD ID		05581	00401
Ensembl ID		ENSG00000171860	ENSG00000244731
Uniprot IDs		A8K2H7 Q16581	P0C0L4
PDB IDs			1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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