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TRAF3 and CD40
Data Source:
HPRD
(in vivo, in vitro, two hybrid)
TRAF3
CD40
Description
TNF receptor associated factor 3
CD40 molecule
Image
GO Annotations
Cellular Component
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Plasma Membrane Signaling Receptor Complex
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Biological Process
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Apoptotic Process
Signal Transduction
Toll Signaling Pathway
Protein Deubiquitination
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of JNK Cascade
Regulation Of Defense Response To Virus
Protein K63-linked Ubiquitination
Positive Regulation Of Protein Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Inflammatory Response
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cobalamin
Response To Interferon-gamma
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Defense Response To Protozoan
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Lucatumumab
Dacetuzumab
Diseases
Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Adult body size (
32376654
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Asthma (
32296059
)
Asthma (childhood onset) (
30929738
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Eczema (
31361310
)
Gallstone disease (
30692554
)
HDL cholesterol levels (
32203549
)
Immunoglobulin measurement (zinc sulfate turbidity test) (
29403010
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Red blood cell count (
32888494
)
Serum total protein level (
29403010
)
Systemic lupus erythematosus (
33536424
28714469
)
Type 2 diabetes (
32499647
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
28067908
23128233
)
Kawasaki disease (
22446961
33106546
22446962
)
Multiple sclerosis (
22190364
24076602
19525955
21833088
)
Rheumatoid arthritis (
30423114
18794853
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
83 interacting genes:
ABCC1
ALPL
APOBEC3C
ASCC1
AZI2
BEX3
BIRC3
BIVM
C10orf62
CASP3
CCDC13
CCDC184
CD27
CD40
CDC37
CELF2
CSNK1E
DAXX
EDA2R
EDAR
EWSR1
FAS
GMEB2
GRIN1
GRIN2D
HEMGN
HNRNPC
HSPB11
IL15
IP6K3
IRF1
LNX1
LTBR
MAP2K1
MAP3K14
MAP3K7
NTAQ1
NUP62
OTUD5
PDLIM7
PDZD4
PIAS2
POM121
PSMB8
RAD23A
RIPK1
RIPPLY1
RNF216
RNF4
RRAS2
SAR1A
SNAP29
SRC
STK38
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM37
UBE2I
USP7
ZBP1
ZBTB49
ZMYND11
ZSCAN4
44 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MFSD5
MIP
MS4A1
NCOA6
NSMAF
PIK3R1
PLP1
RIPK2
SLC30A2
SLC30A3
SLC39A13
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
XRCC5
XRCC6
Entrez ID
7187
958
HPRD ID
03539
00178
Ensembl ID
ENSG00000131323
ENSG00000101017
Uniprot IDs
A6NHG8
Q13114
A0A0S2Z349
A0A0S2Z3C7
P25942
Q6P2H9
PDB IDs
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
1CDF
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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