NR2C1 and SYNE2

Data Source:
BioGRID (two hybrid)

		NR2C1	SYNE2
Description		nuclear receptor subfamily 2 group C member 1	spectrin repeat containing nuclear envelope protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm PML Body	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Meiotic synapsis
Drugs
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Body fat mass ( 28552196) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254) Intracranial aneurysm ( 33199917) Trunk fat mass ( 28552196)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA	11 interacting genes: ABI1 ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML SASH1 UBC
Entrez ID		7181	23224
HPRD ID		03318	09763
Ensembl ID		ENSG00000120798	ENSG00000054654
Uniprot IDs		H9NIM2 H9NIM3 P13056	Q6MZP0 Q8WXH0
PDB IDs			4DXS 4FI9
Enriched GO Terms of Interacting Partners?
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