C1S and C1R

Data Source:
HPRD (in vivo, in vitro)

		C1S	C1R
Description		complement C1s	complement C1r
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lung cancer in never smokers ( 28604730) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: C1QA C1R REEP4 SERPING1 VKORC1	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		716	715
HPRD ID		00397	01954
Ensembl ID		ENSG00000182326	ENSG00000159403
Uniprot IDs		F8WCZ6 P09871	P00736
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39
Enriched GO Terms of Interacting Partners?
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