TOP3A and TDRD3

Data Source:
BioGRID (x-ray crystallography, pull down)

		TOP3A	TDRD3
Description		DNA topoisomerase III alpha	tudor domain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrial Matrix PML Body	Nucleus Nucleoplasm Golgi Apparatus Cytosol Exon-exon Junction Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Methylated Histone Binding
	Biological Process	DNA Replication DNA Topological Change Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Organization Positive Regulation Of Transcription, DNA-templated
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)	Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: BLM RECQL5 TDRD3	6 interacting genes: FUS H3-4 POLR2A TOP3A UBC USP9X
Entrez ID		7156	81550
HPRD ID		03145	11625
Ensembl ID		ENSG00000177302	ENSG00000083544
Uniprot IDs		B4DSJ0 Q13472	A0A024QZE0 Q9H7E2
PDB IDs		4CGY 4CHT	1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T
Enriched GO Terms of Interacting Partners?
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