TRAPPC10 and TRPM2

Data Source:
BioGRID (proximity labelling technology)

		TRAPPC10	TRPM2
Description		trafficking protein particle complex subunit 10	transient receptor potential cation channel subfamily M member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol TRAPP Complex TRAPPII Protein Complex	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Intra-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport COPII Vesicle Coating	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Purine-containing Compound Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Neutrophil Degranulation Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Regulation Of Actin Cytoskeleton Reorganization
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	TRP channels Neutrophil degranulation
Drugs
Diseases
GWAS			Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		5 interacting genes: TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8	3 interacting genes: EFHC1 ITPR3 TRPC6
Entrez ID		7109	7226
HPRD ID		03656	04777
Ensembl ID		ENSG00000160218	ENSG00000142185
Uniprot IDs		P48553	B4DVI8 O94759 Q14DR2
PDB IDs			6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU
Enriched GO Terms of Interacting Partners?
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