TLE3 and FOXG1

Data Source:
HPRD (in vivo)

		TLE3	FOXG1
Description		TLE family member 3, transcriptional corepressor	forkhead box G1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Brain Development Aging Dorsal/ventral Pattern Formation Axon Midline Choice Point Recognition Pyramidal Neuron Migration Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Neuron Fate Determination
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression	Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Rett syndrome
GWAS		Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033 32439900) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		18 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX2 SIX3 TCF7L2 XIAP	19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6
Entrez ID		7090	2290
HPRD ID		02558	01283
Ensembl ID		ENSG00000140332	ENSG00000176165
Uniprot IDs		B3KUA2 H0YL70 Q04726 Q6PRX3	P55316
PDB IDs			7CBY
Enriched GO Terms of Interacting Partners?
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