TLE2 and FOXA3

Data Source:
BioGRID (two hybrid)

		TLE2	FOXA3
Description		TLE family member 2, transcriptional corepressor	forkhead box A3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body	Chromatin Nucleus Nucleoplasm Actin Cytoskeleton
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Cellular Glucose Homeostasis Chromatin Organization Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Cellular Response To Starvation Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Homeostasis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Asthma ( 31959851 32296059) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	5 interacting genes: ALX4 HMGB1 PPARA TLE1 TLE2
Entrez ID		7089	3171
HPRD ID		03025	03802
Ensembl ID		ENSG00000065717	ENSG00000170608
Uniprot IDs		K7EMK7 Q04725	A0A024R0R3 P55318
PDB IDs			1VTN
Enriched GO Terms of Interacting Partners?
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