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ICAM5 and ITGB2
Data Source:
HPRD
(in vitro)
ICAM5
ITGB2
Description
intercellular adhesion molecule 5
integrin subunit beta 2
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin AlphaL-beta2 Complex
Integrin AlphaM-beta2 Complex
Integrin AlphaX-beta2 Complex
Specific Granule Membrane
Receptor Complex
Plasma Membrane Raft
Extracellular Exosome
Tertiary Granule Membrane
Cytoplasmic Region
Ficolin-1-rich Granule Membrane
Extracellular Vesicle
Molecular Function
Integrin Binding
Protein Binding
Amyloid-beta Binding
Complement Component C3b Binding
Integrin Binding
Protein Binding
Protein Kinase Binding
ICAM-3 Receptor Activity
Heat Shock Protein Binding
Cargo Receptor Activity
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Phagocytosis
Cell Adhesion
Extracellular Matrix Organization
Regulation Of Immune Response
Cell-cell Adhesion
Microglial Cell Activation
Leukocyte Migration Involved In Inflammatory Response
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Apoptotic Process
Inflammatory Response
Cell Adhesion
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Aging
Regulation Of Cell Shape
Cell Migration
Cytokine-mediated Signaling Pathway
Natural Killer Cell Activation
Extracellular Matrix Organization
Neutrophil Chemotaxis
Receptor Internalization
Positive Regulation Of Superoxide Anion Generation
Cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Toll-like Receptor 4 Signaling Pathway
Endodermal Cell Differentiation
Receptor Clustering
Neutrophil Degranulation
Positive Regulation Of Neutrophil Degranulation
Endothelial Cell Migration
Cellular Extravasation
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Dopamine Metabolic Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Protein Targeting To Membrane
Amyloid-beta Clearance
Cell-cell Adhesion
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Neuron Death
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Neutrophil Migration
Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Toll Like Receptor 4 (TLR4) Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Drugs
Diseases
Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Inflammatory skin disease (
25574825
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
White blood cell count (
27863252
)
Heel bone mineral density (
28869591
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
5 interacting genes:
ACTN1
ITGAL
ITGB2
PSEN1
PSEN2
56 interacting genes:
ADAMTSL4
APOL2
C3
CD14
CD226
CD82
COPS3
COPS5
CYSRT1
CYTH1
CYTH2
DAB1
DOK1
EGFR
ESM1
FCER2
FHL2
FUT4
HP
ICAM1
ICAM2
ICAM3
ICAM4
ICAM5
ILK
ITGAD
ITGAM
ITGAX
KNG1
KRT31
KRTAP10-8
LHFPL5
MS4A7
MTIF3
NBPF19
NOTCH2NLA
NUMB
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRTN3
PTK2
PTK2B
RACK1
RANBP9
RDX
SCML1
SHARPIN
SYK
TLN1
TM4SF18
UPK1B
VNN2
Entrez ID
7087
3689
HPRD ID
03509
02506
Ensembl ID
ENSG00000105376
ENSG00000160255
Uniprot IDs
Q8N6I2
Q9UMF0
A0A494C0X7
B4E0R1
P05107
PDB IDs
3BN3
4OI9
4OIA
4OIB
1JX3
1L3Y
1YUK
2JF1
2P26
2P28
2V7D
3K6S
3K71
3K72
4NEH
4NEN
5E6R
5E6S
5E6U
5E6V
5E6W
5E6X
5ES4
5XR1
5ZAZ
Enriched GO Terms of Interacting Partners
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