TIMP4 and MMP2

Data Source:
HPRD (in vitro)

		TIMP4	MMP2
Description		TIMP metallopeptidase inhibitor 4	matrix metallopeptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Sarcomere Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Notch Signaling Pathway Central Nervous System Development Biological_process Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Lipopolysaccharide Response To Cytokine Response To Drug Ovulation Cycle Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Blood protein levels ( 30072576 29875488) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ERRFI1 MMP14 MMP2	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7079	4313
HPRD ID		03557	00386
Ensembl ID		ENSG00000157150	ENSG00000087245
Uniprot IDs		Q99727	A0A024R6R4 P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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