TIA1 and WBP4

Data Source:
BioGRID (two hybrid)

		TIA1	WBP4
Description		TIA1 cytotoxic granule associated RNA binding protein	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Stress Granule Ribonucleoprotein Complex	Nucleus Nucleoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	RNA Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding	RNA Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Cytokine Production Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Epithelial Cell Apoptotic Process	MRNA Splicing, Via Spliceosome RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		FGFR2 alternative splicing	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Male-pattern baldness ( 28196072)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		2 interacting genes: FASTK WBP4	54 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DHX38 DIAPH1 DNM2 EFTUD2 EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 NONO PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP200 SNRNP70 SNRPA SNRPB SNW1 TCERG1 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		7072	11193
HPRD ID		04626	16086
Ensembl ID		ENSG00000116001	ENSG00000120688
Uniprot IDs		P31483	O75554
PDB IDs		2MJN 3BS9 5ITH 5O2V 5O3J 6ELD	2DK1 2JXW 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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