TGFB3 and FMOD

Data Source:
HPRD (in vitro)

		TGFB3	FMOD
Description		transforming growth factor beta 3	fibromodulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Platelet Alpha Granule Lumen Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding	Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Female Pregnancy Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Wound Healing Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly	Transforming Growth Factor Beta Receptor Complex Assembly Keratan Sulfate Biosynthetic Process Collagen Fibril Organization Keratan Sulfate Catabolic Process
Pathways		Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans	Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		1,4-Dioxane
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Ossification of the posterior longitudinal ligament of spine (OPLL) Allograft rejection Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS			Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN	4 interacting genes: FBXO7 TGFB1 TGFB2 TGFB3
Entrez ID		7043	2331
HPRD ID		01829	02591
Ensembl ID		ENSG00000119699	ENSG00000122176
Uniprot IDs		A5YM40 B3KVH9 P10600	A0A024R971 B3KS64 Q06828 Q12833
PDB IDs		1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9	5MX0
Enriched GO Terms of Interacting Partners?
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