DYNLT1 and SYNJ2

Data Source:
BioGRID (affinity chromatography technology)

		DYNLT1	SYNJ2
Description		dynein light chain Tctex-type 1	synaptojanin 2
Image
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen	Cytosol Cytoskeleton Plasma Membrane Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Identical Protein Binding	RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Neutrophil Degranulation Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus	Phosphatidylinositol Biosynthetic Process Brain Development Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization
Pathways		Neutrophil degranulation	Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)
Interacting Genes		50 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 DYNLT2B DYNLT3 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP
Entrez ID		6993	8871
HPRD ID		15987	10259
Ensembl ID		ENSG00000146425	ENSG00000078269
Uniprot IDs		P63172	A0A1W2PR85 B4DG94 O15056
PDB IDs		5JPW	1UFW
Enriched GO Terms of Interacting Partners?
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