ELOC and SKAP1

Data Source:
BioGRID (affinity chromatography technology)

		ELOC	SKAP1
Description		elongin C	src kinase associated phosphoprotein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol VCB Complex Cul2-RING Ubiquitin Ligase Complex Elongin Complex	Immunological Synapse Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Body mass index ( 28892062 25673413) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		35 interacting genes: ASB11 CBX5 CENPC COMMD1 CPTP CUL2 CUL3 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3P ELOB EPOR GHR ID2 JTB LRRC41 MCM7 MED8 METTL21C MRAS NOTCH4 PRAME RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 USP33 VHL WNT7B ZYG11B	13 interacting genes: APP BLCAP DYNLL2 FAM102A FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		6921	8631
HPRD ID		02875	05396
Ensembl ID		ENSG00000154582	ENSG00000141293
Uniprot IDs		A0A024R7Y5 Q15369	Q86WV1 V9HW03
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6P59 6R7F 6R7H 6R7N 6SIS 6V9H 6ZHC	1U5D
Enriched GO Terms of Interacting Partners?
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