TBX1 and PRODH

Data Source:
BioGRID (affinity chromatography technology)

		TBX1	PRODH
Description		T-box transcription factor 1	proline dehydrogenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Proline Dehydrogenase Activity FAD Binding
	Biological Process	Angiogenesis Blood Vessel Development Cell Fate Specification Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Lymph Vessel Development Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Muscle Organ Development Sensory Perception Of Sound Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Vagus Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Social Behavior Aorta Morphogenesis Ear Morphogenesis Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Tongue Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Blood Vessel Morphogenesis Thymus Development Muscle Organ Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Semicircular Canal Morphogenesis Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Parathyroid Gland Development Soft Palate Development Pharyngeal System Development Face Morphogenesis Muscle Tissue Morphogenesis Coronary Artery Morphogenesis Enamel Mineralization Cellular Response To Retinoic Acid Cochlea Morphogenesis Mesenchymal Cell Apoptotic Process Regulation Of Animal Organ Morphogenesis Positive Regulation Of Tongue Muscle Cell Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process	Proline Metabolic Process Proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Proline Catabolic Process To Glutamate Positive Regulation Of Cell Death 4-hydroxyproline Catabolic Process
Pathways			Proline catabolism
Drugs			Proline
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Velocardiofacial syndrome	Hyperprolinemia (HP)
GWAS		Acute kidney injury in critical illness ( 27576016) Adolescent idiopathic scoliosis ( 31417091) Childhood ear infection ( 27182965 28928442) DNA methylation (parent-of-origin) ( 23725790) Interleukin-10 levels ( 22205395) Myringotomy ( 28928442) Prostate cancer ( 25217961) Rheumatoid arthritis ( 30891314) Schizophrenia ( 26198764) Tonsillectomy ( 27182965 28928442)	Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235) White blood cell count ( 32888494)
Interacting Genes
Entrez ID		6899	5625
HPRD ID		09069	08433
Ensembl ID		ENSG00000184058	ENSG00000100033
Uniprot IDs		D9ZGG0 O43435 Q152R5	O43272
PDB IDs		4A04
Enriched GO Terms of Interacting Partners?
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