VAMP2 and SLC6A4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer)

		VAMP2	SLC6A4
Description		vesicle associated membrane protein 2	solute carrier family 6 member 4
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GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Clathrin-coated Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Neuron Projection Membrane Raft Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane Serotonergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Protein Self-association Calcium-dependent Protein Binding	Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Syntaxin-1 Binding Cocaine Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Neurotransmitter Secretion Response To Glucose Glutamate Secretion Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Organization Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell	Response To Hypoxia Neurotransmitter Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Serotonin Uptake Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Serotonin clearance from the synaptic cleft
Drugs		Botulinum Toxin Type B	Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196)
Interacting Genes		47 interacting genes: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNAP29 STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21	6 interacting genes: CALR CANX GPM6B STX1A VAMP2 YBX1
Entrez ID		6844	6532
HPRD ID		01717	01640
Ensembl ID		ENSG00000220205	ENSG00000108576
Uniprot IDs		F8WCA0 P63027	B2R7Y7 P31645
PDB IDs		3FIE 3FII 3RK2 3RK3 3RL0	5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C
Enriched GO Terms of Interacting Partners?
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