SP100 and POLR3C

Data Source:
BioGRID (two hybrid)

		SP100	POLR3C
Description		SP100 nuclear antigen	RNA polymerase III subunit C
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Mre11 Complex	Nucleoplasm RNA Polymerase III Complex Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Dimerization Activity Chromo Shadow Domain Binding	Single-stranded DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of Protein Location Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		SUMOylation of DNA damage response and repair proteins Interferon gamma signaling	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		39 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML POLR3C RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A	39 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD PAX6 PICK1 PNMA5 POLR3G POLR3GL POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN
Entrez ID		6672	10623
HPRD ID		06844	17880
Ensembl ID		ENSG00000067066	ENSG00000186141
Uniprot IDs		P23497 Q6ZMK3	Q9BUI4
PDB IDs		1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P	2XUB 2XV4 5AFQ
Enriched GO Terms of Interacting Partners?
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