SP4 and FOXP2

Data Source:
BioGRID (two hybrid, two hybrid)

		SP4	FOXP2
Description		Sp4 transcription factor	forkhead box P2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Caudate Nucleus Development Putamen Development Cerebral Cortex Development Response To Testosterone Negative Regulation Of Transcription, DNA-templated Innate Vocalization Behavior
Pathways
Drugs
Diseases			Speech-language disorder 1 (SPCH1)
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) LDL cholesterol levels ( 32203549) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737) Plateletcrit ( 32888494) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 27798627) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Self-reported risk-taking behaviour ( 30271922 30181555) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)
Interacting Genes		34 interacting genes: - ADAM15 AP1M1 ATXN7L1 BANP CIB3 COL8A1 E2F1 ELK3 FOXP2 GTF2A1 HIVEP1 HYPK LMO3 LNX1 MCRS1 NFYC NKX3-1 NRF1 PELI2 PNKP POGZ POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E SERF2 SP1 SPANXN2 SPANXN3 VEZF1 ZBTB7A	15 interacting genes: CCNC CDK3 CTBP1 CTBP2 FAM124A FOXP1 FOXP4 LNX1 MAPK3 PIN1 RPIA SDCBP SP4 TLE5 TSACC
Entrez ID		6671	93986
HPRD ID		02764	05611
Ensembl ID		ENSG00000105866	ENSG00000128573
Uniprot IDs		A0A3B3IRW4 Q02446 Q32M51	B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2
PDB IDs			2A07 2AS5
Enriched GO Terms of Interacting Partners?
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