SORL1 and GGA2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SORL1	GGA2
Description		sortilin related receptor 1	golgi associated, gamma adaptin ear containing, ARF binding protein 2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding	Protein Binding Small GTPase Binding
	Biological Process	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Protein Localization To Golgi Apparatus Insulin Receptor Recycling Negative Regulation Of MAP Kinase Activity Cellular Protein Metabolic Process Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Death Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process
Pathways		Amyloid fiber formation	TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)
Interacting Genes		10 interacting genes: APOE FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1	36 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 MEMO1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18
Entrez ID		6653	23062
HPRD ID		03595	09347
Ensembl ID		ENSG00000137642	ENSG00000103365
Uniprot IDs		A0A024R3H2 Q92673	Q9UJY4
PDB IDs		2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ	1MHQ
Enriched GO Terms of Interacting Partners?
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