SOD2 and KIAA1549

Data Source:
HPRD (two hybrid)

		SOD2	KIAA1549
Description		superoxide dismutase 2	KIAA1549
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Photoreceptor Connecting Cilium
	Molecular Function	DNA Binding Superoxide Dismutase Activity Protein Binding Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Radiation Response To Cold Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Cellular Response To Oxidative Stress Interleukin-12-mediated Signaling Pathway Response To Isolation Stress Response To Immobilization Stress Response To Drug Response To Hydrogen Peroxide Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Signaling by BRAF and RAF fusions
Drugs		Benzylsulfonic acid 3-Fluoro-L-tyrosine
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)	Heel bone mineral density ( 30598549)
Interacting Genes		9 interacting genes: APP CEP70 CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A	10 interacting genes: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16
Entrez ID		6648	57670
HPRD ID		00938	13873
Ensembl ID		ENSG00000112096	ENSG00000122778
Uniprot IDs		A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59	Q9HCM3
PDB IDs		1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9
Enriched GO Terms of Interacting Partners?
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