FSCN1 and NGFR

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FSCN1	NGFR
Description		fascin actin-bundling protein 1	nerve growth factor receptor
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Podosome Cytoplasm Cytosol Cytoskeleton Microvillus Cell-cell Junction Cell Cortex Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Projection Membrane Microspike Extracellular Exosome	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Integral Component Of Membrane Growth Cone Dendritic Spine Perikaryon
	Molecular Function	RNA Binding Actin Binding Protein Binding Drug Binding Protein-macromolecule Adaptor Activity Cadherin Binding Actin Filament Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Assembly Cell Migration Cytokine-mediated Signaling Pathway Microspike Assembly Actin Cytoskeleton Organization Parallel Actin Filament Bundle Assembly Regulation Of Microvillus Assembly Regulation Of Actin Cytoskeleton Organization Establishment Of Apical/basal Cell Polarity Cell Motility Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Extracellular Matrix Disassembly	Cellular Glucose Homeostasis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Rho Protein Signal Transduction Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		12 interacting genes: ACTA1 ACTC1 CTNNB1 DNAJB9 MAPK8IP2 NGFR OXTR PRKCA PRKCD RAB1A SMURF1 YWHAQ	48 interacting genes: ANXA7 BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274
Entrez ID		6624	4804
HPRD ID		04068	01197
Ensembl ID		ENSG00000075618	ENSG00000064300
Uniprot IDs		A0A384MEG1 B3KTA3 Q16658	P08138
PDB IDs		1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18	2N80 2N83 2N97 3EWV 5ZGG
Enriched GO Terms of Interacting Partners?
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