HLTF and WBP4

Data Source:
BioGRID (pull down)

		HLTF	WBP4
Description		helicase like transcription factor	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Nucleus Nucleoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Chromatin Organization Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		13 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	54 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DHX38 DIAPH1 DNM2 EFTUD2 EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 NONO PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP200 SNRNP70 SNRPA SNRPB SNW1 TCERG1 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		6596	11193
HPRD ID		04461	16086
Ensembl ID		ENSG00000071794	ENSG00000120688
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	O75554
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS	2DK1 2JXW 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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