SLIT1 and GPC1

Data Source:
HPRD (in vivo)

		SLIT1	GPC1
Description		slit guidance ligand 1	glypican 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space Nucleoplasm Endosome Golgi Lumen Cytosol Plasma Membrane Cell Surface Extracellular Matrix Intrinsic Component Of Plasma Membrane Lysosomal Lumen Membrane Raft Synapse Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding Roundabout Binding	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding
	Biological Process	Nuclear Migration Axon Guidance Motor Neuron Axon Guidance Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Schwann Cell Differentiation Cell Migration Heparan Sulfate Proteoglycan Catabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Migration Regulation Of Protein Localization To Membrane Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Netrin-1 signaling Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Diastolic blood pressure (alcohol consumption interaction) ( 24376456) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Obesity-related traits ( 23251661)	Blood protein levels ( 29875488) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)
Interacting Genes		16 interacting genes: ADAMTSL4 ATN1 CHRDL2 CYSRT1 FHL5 GPC1 HOXA1 KRTAP1-1 KRTAP10-8 KRTAP13-2 KRTAP13-3 MEOX2 MTNR1A ROBO1 TRIM42 ZNF620	5 interacting genes: APP COL18A1 SLIT1 SLIT2 VEGFA
Entrez ID		6585	2817
HPRD ID		04773	02671
Ensembl ID		ENSG00000187122	ENSG00000063660
Uniprot IDs		A6H8V1 O75093	A0A384NPH9 H7C410 P35052
PDB IDs			4ACR 4AD7 4BWE 4YWT
Enriched GO Terms of Interacting Partners?
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