SLC22A5 and SLC9A3R1

Data Source:
HPRD (two hybrid)

		SLC22A5	SLC9A3R1
Description		solute carrier family 22 member 5	SLC9A3 regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Ruffle Nucleus Cytoplasm Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Tip Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Protein Self-association Protein-containing Complex Binding Myosin II Binding Protein N-terminus Binding Dopamine Receptor Binding Growth Factor Receptor Binding
	Biological Process	Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport Carnitine Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Glutathione Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Excretion Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Golgi Localization Negative Regulation Of Protein Kinase B Signaling Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs		Levocarnitine
Diseases		Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 31959851 20860503 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Carotid plaque maximum area ( 32469969) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Low density lipoprotein cholesterol levels ( 29083408 32154731) Maximum stenosis ( 32469969) Mean area of carotid plaque ( 32469969) Mean degree of stenosis ( 32469969) Mean platelet volume ( 32888494) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Sum of carotid plaque area ( 32469969) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Fibrinogen ( 20031577) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: KRT27 KRT34 KRTAP6-3 MTUS2 NBPF19 NOTCH2NLA PDZD3 PDZK1 SH3RF1 SLC9A3R1 SLC9A3R2	61 interacting genes: ABCC2 ABCC4 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PHLPP1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		6584	9368
HPRD ID		04539	05406
Ensembl ID		ENSG00000197375	ENSG00000109062
Uniprot IDs		O76082	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?
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