BMP6 and SOSTDC1

Data Source:
HPRD (in vitro)

		BMP6	SOSTDC1
Description		bone morphogenetic protein 6	sclerostin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Vesicle	Extracellular Space
	Molecular Function	Cytokine Activity Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding	BMP Binding BMP Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Response To Glucocorticoid Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Multicellular Organismal Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Myoblast Differentiation Mammary Gland Bud Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Determination Of Dorsal Identity
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 27841878 30578418) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) White blood cell count ( 32888494)	Response to statin therapy ( 20339536)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1 TDGF1	5 interacting genes: BMP2 BMP4 BMP6 BMP7 CDC20
Entrez ID		654	25928
HPRD ID		00211	15417
Ensembl ID		ENSG00000153162	ENSG00000171243
Uniprot IDs		B4DUF7 P22004 Q4VBA3	A4D125 Q6X4U4
PDB IDs		2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?
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