SLC6A2 and RPGRIP1L

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		SLC6A2	RPGRIP1L
Description		solute carrier family 6 member 2	RPGRIP1 like
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Membrane Raft	Nucleoplasm Cytoplasm Centrosome Cytosol Axonemal Microtubule Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Axoneme Photoreceptor Connecting Cilium Ciliary Rootlet Ciliary Transition Zone Ciliary Basal Body
	Molecular Function	Actin Binding Neurotransmitter Transmembrane Transporter Activity Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Protein Binding Thromboxane A2 Receptor Binding
	Biological Process	Neurotransmitter Transport Chemical Synaptic Transmission Monoamine Transport Norepinephrine Transport Sodium Ion Transmembrane Transport Response To Drug Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Neuron Cellular Homeostasis	In Utero Embryonic Development Establishment Of Planar Polarity Kidney Development Liver Development Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cerebellum Development Lateral Ventricle Development Olfactory Bulb Development Corpus Callosum Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Nose Development Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Retinal Rod Cell Development Pericardium Development Cochlea Development Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways		Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs		Amphetamine Phentermine Tramadol Guanadrel Reboxetine Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Methylphenidate Meperidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Cyclobenzaprine Maprotiline Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra sinica root Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Metamfetamine Phendimetrazine Nomifensine Amineptine Debrisoquine Bicifadine Milnacipran XEN2174 DDP-225 CRx-119 Amitifadine Mianserin Tesofensine Tapentadol Trodusquemine Desvenlafaxine Dexmethylphenidate Levomilnacipran Vortioxetine Dosulepin Viloxazine Zotepine Dasotraline Netarsudil Solriamfetol
Diseases		Orthostatic intolerance (OI); Postural tachycardia syndrome (POTS)	Joubert syndrome COACH syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)	Bipolar disorder ( 21254220) Bipolar disorder or body mass index ( 31754094) Body mass index ( 29273807) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Plasma anti-thyroglobulin levels ( 29678681) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Weight ( 28552196)
Interacting Genes		2 interacting genes: PPP2R1A STX1A	1 interacting genes: TBXA2R
Entrez ID		6530	23322
HPRD ID		01232	17204
Ensembl ID		ENSG00000103546	ENSG00000103494
Uniprot IDs		A0A024R6T9 H3BRE9 P23975	A0A087WX34 B7ZKJ9 H3BPS4 H3BV03 I3L1B5 Q68CZ1
PDB IDs			2YRB
Enriched GO Terms of Interacting Partners?
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