SLC5A2 and SERPINB7

Data Source:
HPRD (in vivo)

		SLC5A2	SERPINB7
Description		solute carrier family 5 member 2	serpin family B member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Extracellular Space Cytoplasm
	Molecular Function	Low-affinity Glucose:sodium Symporter Activity Glucose:sodium Symporter Activity Alpha-glucoside Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Alpha-glucoside Transport Carbohydrate Metabolic Process Sodium Ion Transport Hexose Transmembrane Transport Glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane	Negative Regulation Of Endopeptidase Activity Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)
Drugs		Dapagliflozin Canagliflozin Empagliflozin Ertugliflozin
Diseases
GWAS		Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)
Interacting Genes		1 interacting genes: AQP2
Entrez ID		6524	8710
HPRD ID		08919	04524
Ensembl ID		ENSG00000140675	ENSG00000166396
Uniprot IDs		P31639	A8K3Q8 O75635
PDB IDs
Enriched GO Terms of Interacting Partners?
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