BMP4 and BGN

Data Source:
HPRD (in vivo)

		BMP4	BGN
Description		bone morphogenetic protein 4	biglycan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity BMP Receptor Binding	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Germ Cell Development Endoderm Development Mesodermal Cell Fate Determination Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Coronary Vasculature Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To BMP Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Cell Proliferation Involved In Outflow Tract Morphogenesis Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Blood Vessel Remodeling Biological_process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Bone Development Articular Cartilage Development
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Calcium
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Colorectal cancer ( 25990418 19011631 26151821) Colorectal cancer or advanced adenoma ( 30510241) Dental caries ( 23259602) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Logical memory (delayed recall) in normal cognition ( 29274321) Lung function (FEV1/FVC) ( 30804560) Monobrow thickness ( 26926045) Myopia ( 27182965) Optic cup area ( 25631615) Optic disc size ( 31809533) Parkinson's disease ( 19915575) Peak expiratory flow ( 30804560) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TDGF1 TWSG1 ZFYVE9	17 interacting genes: - APOB APP BMP4 CCN4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 TNF
Entrez ID		652	633
HPRD ID		00207	02359
Ensembl ID		ENSG00000125378	ENSG00000182492
Uniprot IDs		P12644 Q53XC5	B4DNL4 P21810
PDB IDs
Enriched GO Terms of Interacting Partners?
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