STIL and USP9X

Data Source:
BioGRID (enzymatic study)

		STIL	USP9X
Description		STIL centriolar assembly protein	ubiquitin specific peptidase 9 X-linked
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GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol	Nucleus Cytoplasm Cytosol Membrane Growth Cone
	Molecular Function	Protein Binding Identical Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Embryonic Axis Specification In Utero Embryonic Development Neural Tube Closure Heart Looping Mitotic Spindle Organization Smoothened Signaling Pathway Determination Of Left/right Symmetry Neural Tube Development Forebrain Development Notochord Development Floor Plate Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Centrosome Duplication Protein Localization To Centrosome	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Protein Targeting To Peroxisome Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Cell Migration Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Regulation Of Circadian Rhythm Cellular Protein Metabolic Process Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Migraine ( 27322543)
Interacting Genes		2 interacting genes: PIN1 USP9X	25 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RNF115 SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL
Entrez ID		6491	8239
HPRD ID		01627	02091
Ensembl ID		ENSG00000123473	ENSG00000124486
Uniprot IDs		A0A0A0MR87 B7ZLW5 E9PSF2 Q15468 Q7Z626	Q6P468 Q86X58 Q93008
PDB IDs		4YYP 5LHW 5LHZ	5VBD 5WCH
Enriched GO Terms of Interacting Partners?
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